Breast cancer, 10 new cancer risk genes identified. To help early diagnosis | Health - Hindustan Times
close_game
close_game

Breast cancer, 10 new cancer risk genes identified. To help early diagnosis

Indo Asian News Service | By
Jul 12, 2018 01:47 PM IST

There are many genetic causes of cancer. While some mutations are inherited from parents, others are acquired all throughout life due to external factors or due to mistakes in copying DNA.

Using publicly available data, researchers have identified 10 new genes that are predisposed to ovarian and breast cancer among others, an advance that would contribute to improving cancer diagnoses and prevention in the future.

A team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.(Shutterstock)
A team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.(Shutterstock)

There are many genetic causes of cancer. While some mutations are inherited from parents, others are acquired all throughout life due to external factors or due to mistakes in copying DNA. In the study, published in Nature Communications, a team of researchers developed a new statistical method named ALFRED and identified 13 candidate cancer predisposition genes, of which 10 are new from tumour sequencing data.

Hindustan Times - your fastest source for breaking news! Read now.

“We applied our method to the genome sequences of more than 10,000 cancer patients with 30 different tumour types and identified known and new possible cancer predisposition genes that have the potential to contribute substantially to cancer risk,” said principal investigator Ben Lehner, ICREA -- Catalan Institution for Research and Advanced Studies in Spain.

“Our computational method uses an old idea that cancer genes often require ‘two hits’ before they cause cancer. We developed a method that allows us to systematically identify these genes from existing cancer genome datasets,” said Solip Park, from the Centre for Genomic Regulation (CRG) -- a Barcelona-based research facility.

The method allows researchers to find risk variants without a control sample, meaning they do not need to compare cancer patients to groups of healthy people.

“Our results show that the new cancer predisposition genes may have an important role in many types of cancer. For example, they were associated with 14% of ovarian tumours, seven per cent of breast tumours and to about one in 50 of all cancers,” Park said.

Inherited variants in one of the newly-proposed risk genes -- NSD1 -- may also be implicated in at least three out of 1,000 cancer patients, the researchers explained. For the study, the team combined data from many different projects and by applying a new computational method, were able to identify important cancer genes that were not identified by the original studies.

Follow @htlifeandstyle for more

Oscars 2024: From Nominees to Red Carpet Glam! Get Exclusive Coverage on HT. Click Here

Catch your daily dose of Fashion, Health, Festivals, Travel, Relationship, Recipe and all the other Latest Lifestyle News on Hindustan Times Website and APPs
SHARE THIS ARTICLE ON
Share this article
SHARE
Story Saved
Live Score
OPEN APP
Saved Articles
Following
My Reads
Sign out
New Delhi 0C
Friday, March 29, 2024
Start 14 Days Free Trial Subscribe Now
Follow Us On